lupus erythemato?sus (LE) a group of connective tissue disorders primarily affecting women aged 20 to 40, comprising a spectrum of clinical forms in which cutaneous disease may occur with or without systemic involvement. Oct 21, · Lupus is a chronic (long-term) disease that can cause inflammation and pain in any part of your body. It’s an autoimmune disease, which means that your immune system — the body system that usually fights infections — attacks healthy tissue instead. Lupus most commonly affects your: Skin; Joints; Internal organs, like your kidneys and heart.
Lupus is a chronic long-term disease that can cause look whats up my ass and pain in any part of your body. Learn more about lupus signs and symptoms. Inflammation usually happens when your immune system is fighting an infection or an injury.
When lupus makes your immune system attack healthy tissue, it can cause inflammation in lots of different body parts. Symptoms can include swelling and pain. But there are four kinds of lupus:. Anyone can develop lupus. But certain people are at higher risk for lupus, including:.
Read more facts and statistics about lupus. No one knows what causes lupus — but lupus and other autoimmune diseases do run in families. Experts also think it may develop in response to certain hormones like estrogen or environmental triggers. An environmental trigger is something outside the body that can bring on symptoms of lupus — or make them worse. Learn more about possible causes and triggers of lupus. There is no one first sign or symptom of lupus. The early signs and symptoms of lupus are generally the same as the symptoms of lupusincluding extreme fatigue, joint pain, or a butterfly rash.
However, the early signs vary widely from person to person. A doctor can help you with a diagnosis to determine if the symptoms you're feeling could possibly be lupus. To help you, we created the Could It Be Lupus questionnaire. Answer the questions about yourself and your signs and symptoms, and then print out your answers to share with your doctor.
Find out: could it be lupus? Watch this educational and engaging explanation of what lupus is and how it affects people, showing the difficulty to describe, diagnose, treat and live with this complex and unpredictable disease.
Our health educators are available to answer your questions and give you the help you need. Understanding Lupus. Living with Lupus. Advancing Research. Get Involved. About Us. Donate What is it called when snakes shed an Advocate. What is lupus? Impact on Daily Life. Ask a Health Educator. Programs and Services. Anyone with lupus. Health care professionals.
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What are the types of lupus? But there are four kinds of lupus: Systemic lupus erythematosus SLEthe most common form of lupus Cutaneous lupusa form of lupus that is limited to the skin Drug-induced what to send to a funeral instead of flowersa lupus-like disease caused by certain prescription drugs Neonatal lupusa rare condition that affects infants of women who have lupus Who is at risk for developing lupus?
Read more facts and statistics about lupus What causes lupus? Learn more about possible causes and triggers of lupus What are the early symptoms of lupus? Want to print information about lupus? More resources to help you understand lupus. Was this resource helpful? Yes No. Understanding lupus. Last updated: October 21, Get lupus resources and updates. Subscribe to our emails. Close Choose a chapter. Lupus Foundation of America.
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lu·pus er·y·the·ma·to·sus (LE, L.E.),
The patient should avoid exposure to the sun. Skin lesions should be treated with topical corticosteroids, but overuse of these preparations should be avoided. SLE is classified as an autoimmune disease in which the body seems to be unable to maintain normal mechanisms of tolerance to autoantigens.
Activation of T helper cells and B cells results in the production of autoantibodies that attack antigens in the cytoplasm and nucleus of cells and on the surface of blood cells. The exact cause of SLE is unknown: genetic defects, hormonal changes, infection, physical or mental stress, some drugs, immunizations, and environmental triggers sunlight, UV light exposure are possible predisposing factors. See: autoimmune disease ; glomerulonephritis.
Autoantibodies can react with autoantigens to form immune complexes in such large numbers that they cannot be completely excreted; the immune complexes may precipitate within blood vessels, producing inflammation at the site and disrupting the flow of blood and oxygen to tissues.
These deposits are particularly damaging in the glomeruli. Autoantibodies also promote the destruction of cells by stimulating neutrophil and macrophage phagocytic activity, which increases cell destruction from trauma, infection, or drugs.
In , revised criteria for diagnosis of SLE were established. Some drugs can cause a lupus-like syndrome; the most common of these are procainamide, isoniazid, and hydralazine. See: drug-induced systemic lupus erythematosus. The onset of the disease may be acute or insidious. Patients have a wide variety of clinical symptoms, signs, and laboratory findings, but anemia, thrombocytopenia, polyarthritis, polyarthralgia skin rashes, glomerulonephritis, fever, malaise, weight loss, fatigue, and low blood levels of complement are the most common.
Most patients are prone to infection. No cure for SLE exists, and complete remission is rare. Rashes may respond to antimalarials, e. Other treatments for skin rash include quinacrine, retinoids, and dapsone. Life-threatening and severely disabling conditions should be treated with high doses of corticosteroids and supplemental calcium to minimize osteoporosis, which may be an undesired side effect of long-term glucocorticoid use.
Immunosuppressive drugs are used for severe exacerbations and to reduce steroid dosage. The prognosis depends on which organ systems are involved, how severely they are damaged, and how rapidly the disease progresses. Renal failure and infections are the most common causes of death. Patient education related to the disease, diagnostic procedures, and treatment is essential in lupus, as in any chronic disease.
Ongoing assessment is carried out to assess flares of the illness. The purpose, proper dosage, use, and side effects of drugs is taught. Patients need emotional support to help cope with changes in appearance. Patients should be taught to wear clothing and hats that block direct sunlight, use a sunscreen with a 15 or higher protection factor, and to maintain a diet appropriate for their renal functional status.
The health care professional should help establish a regimen for adequate relief of both the musculoskeletal pain and chronic fatigue experienced by most patients, encouraging adequate rest. Heat packs relieve joint stiffness and pain, and regular gentle exercise helps to maintain full range of motion. Physical and occupational therapy consultations are provided as appropriate. Additional support and teaching depend on the organ system most affected by the disease.
If the female patient of childbearing age has no renal or neurologic impairment, she can have a safe, successful pregnancy if desired. Over time, patients with severe progressive disease need assistance in coping with chronic illness and the possibility of mortality. Referrals to the Lupus Foundation of America ; www.
What is Lupus? My best friend has been diagnosed with Lupus. What is it? Is it contagious? No, lupus is not contagious. It cannot be passed from one person to another. Lupus is an autoimmune disease, the cause of which is still unknown. Is a rash a symptom of lupus? My Sister has lupus for several years now.
I recently developed a rash on my face. Is this a symptom of lupus? Could I have also been infected with this disease? Lupus has not been proven to be hereditary. Therefore, the fact your sister has lupus shouldn't cause you to beleive you too will develop it. Also a rash is not enough to diagnose lupus. Physicians have to gather information from a variety of sources: past medical history, lab tests and current symptoms. They use a list of 11 criteria to help diagnose SLE. A person needs to satisfy at least 4 out of the 11 criteria before the diagnosis can be pinpointed.
Some criteria, such as a biopsy diagnosis of kidney lupus, can carry more weight. Related to lupus: Discoid lupus. Although the term is frequently used alone to designate lupus vulgaris and sometimes lupus erythematosus, without a modifier it has no meaning. The Latin word lupus means wolf; erythematosus refers to redness.
The name lupus erythematosus has been used since the 13th century because physicians thought the shape and color of the skin lesions resembled the bite of a wolf. Currently, there are at least two recognized manifestations of the disease: discoid lupus erythematosus and systemic lupus erythematosus.
It may be chronic discoid lupus erythematosus ; subacute systemic lupus erythematosus ; or acute characterized by an acute edematous, erythematous eruption, often with systemic exacerbations. The acute form may be the presenting symptom of systemic lupus erythematosus , such as after sun exposure.
The lesions typically form a butterfly pattern over the bridge of the nose and cheeks, but other areas may be involved, notably the scalp and other areas that are exposed to light. It can, however, affect any organ of the body and usually has periods of remissions and exacerbations. See plate in Dermatology Atlas. It was once thought that this was a fairly rare disease, but improved immunologic testing procedures have shown that it is not.
It is primarily a disease of women, occurring five to ten times more often in females than in males. Although the peak incidence is between 30 and 40 years of age, the condition has also been diagnosed in the very young and the very old. SLE is the classic prototype of autoimmune disease of connective tissue.
Its etiology is unknown, but the high level of autoantibodies in persons with the condition indicates a defect in the regulatory mechanisms that sustain self-tolerance and prevent the body from attacking its own cells, cell constituents, and proteins.
Patients with SLE can have a wide variety of autoantibodies against nuclear and cytoplasmic cellular components. The presence of high levels of antinuclear antibody ANA in SLE patients with glomerulonephritis indicates a pathogenic role for that antibody. The antibodies are directed against deoxyribonucleoprotein, DNA, histone, and a soluble non—nucleic acid molecule called Sm antigen. Factors that appear to contribute to the development of SLE include exposure to sunlight or ultraviolet radiation from sunlamps, a genetic predisposition to the disease, certain drugs, viral infections, and hormonal influences.
Clinical manifestations of SLE are confusingly diverse owing to the involvement of connective tissue throughout the body. Typically, the patient seeks medical help for relief of fever, weight loss, joint pain, the characteristic butterfly rash, pleural effusion and pleuritic pain, and nephritis.
Either glomerulonephritis , which is usually mild, or cardiovascular manifestations such as myocarditis , endocarditis , or pericarditis , are found in about half the patients with SLE. Pulmonary disease, especially pleurisy , is also relatively common, as are gastrointestinal disturbances and lymph node involvement.
Organic neurologic disturbances produce behavioral aberrations and frank psychosis in some patients; in a few others, there are peripheral neuropathies , motor weakness, and diplopia. Supportive measures are used to prevent or minimize acute relapses and exacerbations of symptoms.
The patient is instructed to avoid exposure to sunlight and ultraviolet radiation from other sources, blood transfusions, penicillin, and the sulfonamides. Active disease is treated with topical steroids , nonsteroidal antiinflammatory drugs for fever and joint pain, corticosteroids , and immunosuppressants. The goal of drug therapy is suppression of the immune system.
Treatment of specific manifestations of SLE is aimed at prevention of complications. Physical therapy may be required to alleviate muscle weakness and prevent orthopedic deformities. All rights reserved. A term originally used to depict erosion as if gnawed of the skin, now used with modifying terms designating the various diseases listed below.
See systemic lupus erythematosus. Published by Houghton Mifflin Company. Segen's Medical Dictionary. A term originally used to depict erosion as if gnawed of the skin, now used with modifying terms designating different varieties of the disease.
Originally any chronic, progressive, usually ulcerating, skin disease. In current usage, when the word is used alone, it has no precise meaning. A chronic skin disease characterized by periodic acute appearances of a scaling, red, macular rash.
DLE is caused by an autoimmune process involving both B-cell— and T-cell—mediated mechanisms that destroy the skin's basal cells. DLE is treated with topical corticosteroids. See: autoimmune disease ; systemic lupus erythematosus Treatment The patient should avoid exposure to the sun.
A group of signs and symptoms similar to those of systemic lupus erythematosus, caused by an adverse reaction to drugs, esp. Joint inflammation and pain, skin rash, pleurisy, and fever are the most common manifestations; kidney and central nervous system involvement are rare. Antinuclear antibodies, specifically against the histones that fold DNA, are common.
Some patients develop antinuclear antibodies but do not develop lupus-like symptoms.
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