Insulin-like Growth Factor-1 Test
Insulin-like growth factor-1 (IGF-1) is a hormone that, along with growth hormone (GH), helps promote normal bone and tissue growth and development. The test measures the amount of IGF-1 in the blood. IGF-1 is primarily produced in the liver, skeletal muscles, and many other tissues in . This test measures the amount of insulin-like growth factor-1 (IGF-1) in your blood. IGF-1 is a hormone found naturally in your blood. Its main job is to manage the effects of growth hormone (GH) in your body. Normal IGF-1 and GH functions include tissue and bone growth. IGF-1 is formed in different tissues as a result of GH in the blood.
IGF-1 bliod transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations. Measuring IGF-1 is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone Hypopituitarism results in decreased serum levels of IGF-1, while acromegaly growth hormone excess results in elevated levels of IGF This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics.
It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes. For red-top tube no gelallow blood to clot minutes at room temperature. Separate serum from cells and refrigerate. Transport tube. Refrigerated cold packs. Reference ranges are provided as general guidance ks. To interpret test results use the reference range what are the parts of eyes and their functions the laboratory report.
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Jun 09, · Insulin-like Growth Factor-1 (IGF-1). A test for insulin-like growth factor-1 (IGF-1) may be used to help: Identify growth hormone (GH) deficiency; it is not diagnostic of a GH deficiency but may be requested along with GH stimulation tests to offer additional information; Detect GH excess in suspected cases of acromegaly or gigantism. Clinical Significance. IGF-1, LC/MS - Insulin-like Growth Factor 1 (IGF-1, or Somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by Growth Hormone (GH) and nutritional intake. IGF-1 is transported in serum by several proteins; this helps maintain relatively high IGF-1 plasma levels and minimizes fluctuations in serum IGF-1 concentrations.
To identify diseases and conditions caused by deficiencies and overproduction of growth hormone GH , to evaluate pituitary function and to monitor the effectiveness of GH treatment. When a pituitary disorder is suspected; when a person has slow growth, short stature, delayed development or low blood sugar that suggest insufficient GH and IGF-1 production; when you have symptoms of gigantism in children or acromegaly in adults that suggest excess GH and IGF-1 production; during and after treatment for GH abnormalities.
Insulin-like growth factor-1 IGF-1 and growth hormone are hormones that are vital for normal bone and tissue growth and development. GH is produced by the pituitary gland, a grape-sized gland located at the base of the brain behind the bridge of your nose. GH is secreted into the bloodstream in pulses throughout the day and night with peaks that occur mostly during the night. IGF-1 is produced by the liver and to a lesser degree by skeletal muscles, primarily in response to GH stimulation.
It mediates many of the actions of GH, stimulating the growth of bones and other tissues and promoting the production of lean muscle mass. Like GH, IGF-1 levels are normally low in early childhood, increase gradually during childhood, peak during puberty, and then decline in adult life.
Deficiencies in GH and IGF-1 may be caused by conditions such as hypopituitarism or by the presence of a non-GH-producing pituitary tumour that damages hormone-producing cells. This insensitivity may be primary genetic or secondary to conditions such as malnutrition and chronic diseases. Genetic GH insensitivity GH resistance is rare. Deficiencies early in life can inhibit bone growth and overall development and can result in a child with a short stature.
In adults, decreased production can lead to low bone densities, less muscle mass and altered lipids. Excess GH and IGF-1 can cause abnormal growth of the skeleton and other signs and symptoms characteristic of gigantism and acromegaly. In children, gigantism causes bones to grow longer, resulting in a very tall person with large feet and hands. In adults, acromegaly causes bones to thicken and soft tissues, such as the nose, to swell.
Both conditions can lead to enlarged organs, such as the heart, and to other complications such as type 2 diabetes , high blood pressure , increased risk of cardiovascular disease risk, arthritis and a decreased life span.
The most common reason for the pituitary to secrete excessive amounts of GH is a GH-producing pituitary tumour usually benign. In general, no test preparation is needed; however, since this test may be performed at the same time as others, fasting for at least 12 hours may be required.
IGF-1 may be ordered with other pituitary hormone tests, such as adrenocorticotropic hormone ACTH , to help diagnose hypopituitarism.
It may be used to monitor the effectiveness of treatment for GH deficiencies and GH insensitivity. Its presence is then confirmed with imaging scans that help identify and locate the tumour. IGF-1 may be used to monitor the effectiveness of this therapy at regular intervals for years afterward to monitor GH production and to detect tumour recurrence. Insulin-like growth factor-1 IGF-1 testing may be ordered, along with a GH stimulation test when a child has symptoms of GH deficiency, such as a slowed growth rate and short stature.
They also may be ordered when adults have symptoms that the doctor suspects may be due to a GH deficiency. An IGF-1 also may be ordered when a doctor suspects that a person has an underactive pituitary gland and at intervals to monitor patients on GH therapy.
IGF-1 testing may be ordered, along with a GH suppression test , when a child has symptoms of gigantism , an adult shows signs of acromegaly. When a GH-producing pituitary tumour is found, GH and IGF-1 are ordered after the tumour is surgically removed to determine whether all of the tumour has been extracted. Normal concentrations of Insulin-like growth factor-1 IGF-1 must be considered in context. If this is in a child, the GH deficiency may have already caused short stature and delayed development and may be treated with GH supplementation.
Adults will have an age-related decrease in production, but lower than expected concentrations may reflect a GH deficiency or insensitivity. Reduced pituitary function may be due to inherited defects or can rise as a result of pituitary damage following conditions such as trauma, infections and inflammation.
Decreased levels of IGF-1 also may be seen with nutritional deficiencies including anorexia nervosa , chronic kidney or liver disease , and with high doses of oestrogen. Increased concentrations of IGF-1 are most commonly due to pituitary tumours. If IGF-1 is still elevated after the surgical removal of a pituitary tumour, then the surgery may not have been fully effective. When a patient is undergoing long term monitoring, an increase in IGF-1 levels may indicate a recurrence of the pituitary tumour.
Growth hormone GH , Glucose , Glucose tolerance test. Warning Don't risk using unapproved coronavirus test kits More Info. Find an explanation of your pathology test Keyword:. Test name Tests All Tests and synonyms Test not listed? Health check Screening On This Page At a glance What is being tested?
The test Common questions Related information. To identify diseases and conditions caused by deficiencies and overproduction of growth hormone GH , to evaluate pituitary function and to monitor the effectiveness of GH treatment When to get tested? Sample required? A blood sample drawn from a vein in your arm. Test preparation needed? None, unless instructed to fast.
What is being tested? How is the sample collected for testing? A blood sample is obtained by inserting a needle into a vein in the arm. Is any test preparation needed to ensure the quality of the sample? The Test How is it used?
A test for insulin-like growth factor-1 IGF-1 may be used to help: Identify growth hormone GH deficiency; it is not diagnostic of a GH deficiency but may be requested along with GH stimulation tests to offer additional information Detect GH excess in suspected cases of acromegaly or gigantism Evaluate pituitary function; as follow-up to abnormal results on other hormone tests IGF-1 is measured to help diagnose the cause of growth abnormalities and to evaluate pituitary function.
It is not diagnostic of GH deficiency but may be ordered along with GH stimulation tests to offer additional information. About Reference Intervals. In a child, it is unusual tallness that is often first noticed. With an adult, it may be more subtle: a larger nose, thicker lips, a more prominent jaw or rings and shoes that no longer fit.
Other signs and symptoms may include: Deepened, husky voice Enlarged organs - liver, heart, kidneys and spleen Enlarged tongue Erectile dysfunction Fatigue Headaches and visual disturbances Joint pain and swelling Menstrual cycle irregularities Muscle weakness Snoring Sweating and body odor Thickening of the skin, skin tags Trapped nerves Carpal tunnel syndrome.
As long as you are considered to have abnormal low or high GH production or are receiving treatment for one of the conditions your IGF-1 will need to be monitored.